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2014N

  • Ha, N., Pham, D-H., Naruse, C., Asano, M., and Thai, T-H. gHP-1 controls high-affinity antibody response to T-dependent antigens.h Frontiers in Immunology 5: 271, 2014.
  • *Lopatina, O., *Yoshihara, T., *Nishimura, T., Zhong, J., Akther, S., Fakhrul, A.A., Liang, M., Higashida, C., Sumi, K., Furuhara, K., Inahata, Y., Huang, J., Koizumi, K., Yokoyama, S., Tsuji, T., Petugina, Y., Sumarukov, A., Salmina, A.B., Hashida, K., Kitao, Y., Hori, O., Asano, M., Kitamura, Y., Kozaka, T., Shiba, K., Zhong, F., Xie, M-J., Sato, M., Ishihara, K., and Higashida, H. gAnxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinsonfs disease.h Frontiers in Behavioral Neuroscience 8: 133, 2014. *equal contribution.
2013N
  • Cui, H., Okamoto, Y., Yoshioka, K., Du, W., Takuwa, N., Zhang, W., Asano, M., Shibamoto, T., and Takuwa, Y. gSphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. h J. Allergy Clin. Immunol. In press.
  • Ohno, R., Nakayama, M., Naruse, C., Okashita, N., Takano, O., Tachibana, M., Asano, M., Saitou, M., and Seki, Y. gA replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.h Development 140: 2892-2903, 2013.
  • Hase, K., Nakatsu, F., Ohmae, M., Sugihara, K., Shioda, N., Takahashi, D., Obata, Y., Furusawa, Y., Fujimura, Y., Yamashita, T., Fukuda, S., Okamoto, H., Asano, M., Yonemura, S., and Ohno, H. gAP-1B|mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.h Gastroenterology 145: 625-635, 2013.
  • Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M. and Kitagawa, H. gEXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.h J. Biol. Chem. Mar 29;288(13):9321-33, 2013.
  • *Liu, H-X., *Lopatina, O., Higashida, C., Fujimoto, H., Akther, S., Inzhutova, A., Liang, M., Zhong, J., Tsuji, T., Yoshihara, T., Sumi, K., Ishiyama, M., Ma, W-J., Ozaki, M., Yagitani, S., Yokoyama, S., Mukaida, N., Sakurai, T., Hori, O., Yoshioka, K., Hirao, A., Kato, Y., Ishihara, K., Kato, I., Okamoto, H., Cherepanov, S.M., Salmina, A.B., Hirai, H., Asano, M., Brown, D.A., Nagano, I., and Higashida, H. gDisplays of paternal mouse pup retrieval following communicative interaction with maternal mates.h Nat. Commun. 4: 1346, 2013. *equal contribution.
2012N
  • Yoshioka, K., Yoshida, K., Cui, H., Wakayama, T., Takuwa, N., Okamoto, Y., Du, W., Qi, X., Asanuma, K., Sugihara, K., Aki, S., Miyazawa, H., Biswas, K., Nagakura, C., Ueno, M., Iseki, S., Schwartz, J. R., Okamoto, H., Sasaki, T., Matsui, O., Asano, M., Adams, H. R., Takakura, N., and Takuwa, Y. gEndothelial PI3K-C2, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.h Nat. Med. 18: 1560-1569, 2012.
  • Sugahara, D., Kaji, H., Sugihara, K., Asano, M., and Narimatsu, H. gLarge-scale identification of target proteins of a glycosyltransferase isozyme by Lectin-IGOT-LC/MS, an LC/MS-based glycoproteomic approach.h Scientific Reports, 2: 680, 2012.
  • Yamaguchi, K., Shiozaki, K., Moriya, S., Koseki, K., Wada, T., Tateno, H., Sato, I., Asano, M., Iwakura, Y., and Miyagi, T. gReduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase.h PLoS ONE 7: e41132, 2012.
  • Sato, A., Ohtaki, H., Tsumuraya, T., Song, D., Ohara, K., Asano, M., Iwakura, Y., Atsumi, T., and Shioda, S. gInterleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.h J Neuroinflammation 9: 65, 2012.
  • Shinzaki, S., Iijima, H., Fujii H., Kuroki, E., Tatsunaka, N., Inoue, T., Nakajima, S., Egawa, S., Kanto, T, Tsujii, M., Morii, E., Takeishi, S., Asano, M., Takehara, T., Hayashi, N. and Miyoshi, E. gAltered oligosaccharide structures reduce colitis induction in mice defective in -1,4-galactosyltransferase.h Gastroenterology 142: 1172-1182, 2012.
  • Ito, M., Sugihara, K., Asaka, T., Toyama, T., Yoshihara, T., Furuichi, K., Wada, T., Asano, M. gGlycoprotein Hyposialylation Gives Rise to a Nephrotic-Like Syndrome That Is Prevented by Sialic Acid Administration in GNE V572L Point-Mutant Mice.h PLoS ONE7(1): e29873. 2012.

2011N
  • Yamamoto, Y., Harashima, A., Saito, H., Tsuneyama, K., Munesue, S., Motoyoshi, S., Han, D., Watanabe, T., Asano, M., Takasawa, S., Okamoto, H., Shimura, S., Karasawa, T., Yonekura, H., and Yamamoto, H. gSeptic shock is associated with receptor for advanced glycation end products ligation of LPS.h J. Immunol., 186: 3248-3257, 2011.
  • Kouno, T., Kizuka, Y., Nakagawa, N., Yoshihara, T., Asano, M. and Oka, S. "Specific enzyme complex of -1, 4-galactosyltransferase-II and GlcAT-P facilitates biosynthesis of N-linked HNK-1 carbohydrate." J. Biol. Chem. 286: 31337-31346, 2011.
  • *Takada, Y., *Naruse, C., *Costa, Y., Shirakawa, T., Tachibana, M., Sharif, J., Kezuka-Shiotani, F., Kakiuchi, D., Masumoto, H., Shinkai, Y., Ohbo, K., Peters, A.H., Turner, J.M., #Asano, M. and #Koseki, H. "HP1 links histone methylation marks to meiotic synapsis in mice." Development. 2011 Oct;138(19):4207-17. *equal contribution. #equal correspondence.
  • Abe, K., Naruse, C., Kato, T., Nishiuchi, T., Saitou, M., and Asano, M. "Loss of heterochromatin protein 1 reduces the number of primordial germ cells via impaired cell-cycle progression." Biol. Reprod., 85: 1013-1024, 2011.
2010N
  • Nishie T, Hikimochi Y, Zama K, Fukusumi Y, Ito M, Yokoyama H, Naruse C, Ito M, Asano M. "4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development." Glycobiology, 2010 Jun 23.
  • Izumikawa, T., Kanagawa, N., Watamoto, Y., Okada, M., Saeki, M., Sakano, M., Sugahara, K., Sugihara, K., Asano, M., and Kitagawa, H. gImpairment of embryonic cell Division and glycosaminoglycan biosynthesis in glucuronyltransferase-I deficient mice.h J. Biol. Chem., 285: 12190-12196, 2010.
  • Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., Sugihara, K., Kaneko, S., Soga, T., Asano, M., Tomita, M., Matsui, T., Wada, M., and Tsuji, A. gGene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.h Pharm. Res., 27: 832-840, 2010.
  • Zhao, Y., Zhang, X., Guda, K., Lawrence, E., Sun, Q., Watanabe, T., Iwakura, Y., Asano, M., Wei, L., Yang, Z., Zheng, W., Dawn Dawson, D., Willis, J., Markowitz, S.D., Satake, M., and Wang, Z. gIdentification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.h Proc. Natl. Acad. Sci. USA, 107; 2592-2597, 2010.
  • Du, W., Takuwa, N., Yoshioka, K., Okamoto, Y., Gonda, K., Sugihara, K., Fukamizu, A., Asano, M., and Takuwa, Y. gS1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.h Cancer Research 70: 772-781, 2010.
2009N
  • Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J., and Hirao, A. gIdentification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.h Proc. Natl. Acad. Sci. USA 106: 17163-17168, 2009.
  • Takahashi, I., Noguchi, N., Nata, K., Yamada, S., Kaneiwa, T., Mizumoto, S., Ikeda, T., Sugihara, K., Asano, M., Yoshikawa, T., Yamauchi, A., Shervani, N.J., Uruno, A., Kato, I., Unno, M., Sugahara, K., Takasawa, S., Okamoto, H., and Sugawara, A. gImportant role of heparan sulfate in postnatal islet growth and insulin secretion.h Biochem. Biophys. Res. Commun. 383: 113-118, 2009.
  • Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., and Matsuo, K. gBidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.h J. Biol. Chem. 284: 14637-14644, 2009.
  • *Yoshihara, T., *Sugihara, K., Kizuka, Y., Oka, S., and Asano, M. gLearning/memory impairment and reduced expression of the HNK-1 carbohydrate in 4-galactosyltransferase-II-deficient mice.h J. Biol. Chem. 284: 12550-12561, 2009. *equal contribution.
  • *Chan, C.-B., *Abe, M., Hashimoto, N., Hao, C., Williams, I.R., Liu, X., Nakao, S., Yamamoto, A., Li, S.-Y., Hara-Nishimura, I., #Asano, M., and #Ye, K. gMice lacking asparaginyl endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome.h Proc. Natl. Acad. Sci. USA 106: 468-473, 2009. *equal contribution. #equal correspondence.
  • Ueno, M., Itoh, M., Sugihara, K., Asano, M., and Takakura, N. gBoth alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration.h Blood 113: 555-562, 2009.
2008N
  • Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Mol Cell Neurosci. 2008 Dec;39(4):569-78. Epub 2008 Aug 30.
  • Iwanaga A, Wang G, Gantulga D, Sato T, Baljinnyam T, Shimizu K, Takumi K, Hayashi M, Akashi T, Fuse H, Sugihara K, Asano M, Yoshioka K. Ablation of the scaffold protein JLP causes reduced fertility in male mice. Transgenic Res. 2008 Dec;17(6):1045-58. Epub 2008 Jun 24.
  • Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye K. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell. 2008 Mar 28;29(6):665-78.
  • Zhang G, Njauw CN, Park JM, Naruse C, Asano M, Tsao H. EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res. 2008 Mar 15;68(6):1691-6.
  • Kaneda T, Naruse C, Kawashima A, Fujino N, Oshima T, Namura M, Nunoda S, Mori S, Konno T, Ino H, Yamagishi M, Asano M. A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model. Clin Sci (Lond). 2008 Mar;114(6):431-40.
  • Fukusumi Y, Naruse C, Asano M. Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 2008 Mar;237(3):618-29.
2007N
  • Iwanaga A, Sato T, Sugihara K, Hirao A, Takakura N, Okamoto H, Asano M, Yoshioka K. Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Neurosci Lett. 2007 Dec 11;429(1):43-8. Epub 2007 Oct 2.
  • Naruse C, Fukusumi Y, Kakiuchi D, Asano M. A novel gene trapping for identifying genes expressed under the control of specific transcription factors. Biochem Biophys Res Commun. 2007 Sep 14;361(1):109-15. Epub 2007 Jul 10.
  • Morita Y, Araki H, Sugimoto T, Takeuchi K, Yamane T, Maeda T, Yamamoto Y, Nishi K, Asano M, Shirahama-Noda K, Nishimura M, Uzu T, Hara-Nishimura I, Koya D, Kashiwagi A, Ohkubo I. Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. FEBS Lett. 2007 Apr 3;581(7):1417-24. Epub 2007 Mar 5.
  • Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature. 2007 Mar 1;446(7131):41-5. Epub 2007 Feb 7.
  • Nishie T, Miyaishi O, Azuma H, Kameyama A, Naruse C, Hashimoto N, Yokoyama H, Narimatsu H, Wada T, Asano M. Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice. Am J Pathol. 2007 Feb;170(2):447-56.
2006N
  • Myint KM, Yamamoto Y, Doi T, Kato I, Harashima A, Yonekura H, Watanabe T, Shinohara H, Takeuchi M, Tsuneyama K, Hashimoto N, Asano M, Takasawa S, Okamoto H, Yamamoto H. RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin. Diabetes. 2006 Sep;55(9):2510-22.
  • Furuichi K, Wada T, Iwata Y, Kokubo S, Hara A, Yamahana J, Sugaya T, Iwakura Y, Matsushima K, Asano M, Yokoyama H, Kaneko S. Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury. Crit Care Med. 2006 Sep;34(9):2447-55.
  • Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M. Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J Neurochem. 2006 Jun;97(5):1431-46. Epub 2006 Apr 5.
  • Zhu Y, Saito K, Murakami Y, Asano M, Iwakura Y, Seishima M. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neurosci Lett. 2006 Jan 30;393(2-3):122-6. Epub 2005 Dec 13.
2005N
2004N
  • Kagiwada K, Chida D, Sakatani T, Asano M, Nambu A, Kakuta S, Iwakura Y. IL-6, but not IL-1, induction in the brain downstream of Cox-2 is essential for the induction of febrile response against peripheral IL-1. Endocrinology. 2004 Jul ;145(11):5044-8.
  • Kitagawa K, Wada T, Furuichi K, Hashimoto H, Ishiwata Y, Asano M, Takeya M, Kuziel WA, Matsushima K, Mukaida N, Yokoyama H. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol. 2004 Jul;165(1):237-46.
  • Umemura M, Kawabe T, Shudo K, Kidoya H, Fukui M, Asano M, Iwakura Y, Matsuzaki G, Imamura R, Suda T. Involvement of IL-17 in Fas ligand-induced inflammation. Int Immunol. 2004 Aug;16(8):1099-108.
  • Saito T, Okumura A, Watanabe H, Asano M, Ishida-Okawara A, Sakagami J, Sudo K, Hatano-Yokoe Y, Bezbradica JS, Joyce S, Abo T, Iwakura Y, Suzuki K, Yamagoe S. Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J Immunol. 2004 Jul 1;173(1):579-85.
  • Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T. Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver. Drug Metab Dispos. 2004 Jul;32(7):707-14.
  • Kotani N, Asano M, Inoue N, Iwakura Y, Takasaki S. Polylactosamine synthesis and branch formation of N-glycans in beta1,4-galactosyltransferase-1-deficient mice. Arch Biochem Biophys. 2004 Jun 15;426(2):258-65.
  • Mori R, Kondo T, Nishie T, Ohshima T, Asano M. Impairment of skin wound healing in beta-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment. Am J Pathol. 2004 Apr;164(4):1303-14.
  • Kurohara K, Komatsu K, Kurisaki T, Masuda A, Irie N, Asano M, Sudo K, Nabeshima Y, Iwakura Y, Sehara-Fujisawa A. Essential roles of Meltrin beta (ADAM19) in heart development. Dev Biol. 2004 Mar 1;267(1):14-28.
  • Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 1;266(1):178-89.
2003N
  • Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K, Hashimoto H, Ishiwata Y, Asano M, Wang H, Matsushima K, Takeya M, Kuziel WA, Mukaida N, Yokoyama H. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol. 2003 Oct;14(10):2503-15.
  • Inano A, Sai Y, Nikaido H, Hasimoto N, Asano M, Tsuji A, Tamai I. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos. 2003 Nov;24(8):357-65.
  • Nakae, S., Horai, R., Komiyama, Y., Nambu, A., Asano, M., Nakane, A., and Iwakura, Y. The role of IL-1 in the immune system. In Contemporary Immunology: Cytokine Knockouts, 2nd Edition (ed G., Fantuzzi), Humana Press Inc., Totowa, NJ, pp95-109, 2003.
  • Ohtaki H, Funahashi H, Dohi K, Oguro T, Horai R, Asano M, Iwakura Y, Yin L, Matsunaga M, Goto N, Shioda S. Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1. Neurosci Res. 2003 Mar;45(3):313-24.
  • Ohtaki H, Takaki A, Yin L, Dohi K, Nakamachi T, Matsunaga M, Horai R, Asano M, Iwakura Y, Shioda S. Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice. Acta Neurochir Suppl. 2003;86:191-4.
  • Takeda Y, Akasaka K, Lee S, Kobayashi S, Kawano H, Murayama S, Takahashi N, Hashimoto K, Kano M, Asano M, Sudo K, Iwakura Y, Watanabe K. Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup. J Neurobiol. 2003 Sep 5;56(3):252-65.
  • Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I. Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9.
  • Asano M, Nakae S, Kotani N, Shirafuji N, Nambu A, Hashimoto N, Kawashima H, Hirose M, Miyasaka M, Takasaki S, Iwakura Y. Impaired selectin ligand biosynthesis and reduced inflammatory responses in {beta}-1,4-galactosyltransferase-I-deficient mice. Blood. 2003 Sep 1;102(5):1678-85
  • Nakae S, Komiyama Y, Yokoyama H, Nambu A, Umeda M, Iwase M, Homma I, Sudo K, Horai R, Asano M, Iwakura Y. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol. 2003 Apr;15(4):483-90.
  • Li H, Takeda Y, Niki H, Ogawa J, Kobayashi S, Kai N, Akasaka K, Asano M, Sudo K, Iwakura Y, Watanabe K. Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2. Eur J Neurosci. 2003 Mar;17(5):929-36.
  • Ohtaki H, Funahashi H, Dohi K, Oguro T, Horai R, Asano M, Iwakura Y, Yin L, Matsunaga M, Goto N, Shioda S. Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1. Neurosci Res. 2003 Mar;45(3):313-24.
  • Kirii H, Niwa T, Yamada Y, Wada H, Saito K, Iwakura Y, Asano M, Moriwaki H, Seishima M. Lack of Interleukin-1{beta} Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol. 2003 Apr;23(4):656-660.
  • Nakae S, Komiyama Y, Narumi S, Sudo K, Horai R, Tagawa Y, Sekikawa K, Matsushima K, Asano M, Iwakura Y. IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response. Int Immunol. 2003 Feb;15(2):251-60.
  • Kurisaki T, Masuda A, Sudo K, Sakagami J, Higashiyama S, Matsuda Y, Nagabukuro A, Tsuji A, Nabeshima Y, Asano M, Iwakura Y, Sehara-Fujisawa A. Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis. Mol Cell Biol. 2003 Jan;23(1):55-61.

2002N
  • Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, Yonehara S. Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ. 2002 Nov;9(11):1196-206.
  • Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002 Sep;17(3):375-87.
  • Yamamoto S, Oka S, Inoue M, Shimuta M, Manabe T, Takahashi H, Miyamoto M, Asano M, Sakagami J, Sudo K, Iwakura Y, Ono K, Kawasaki T. Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem. 2002 Jul 26;277(30):27227-31.
  • Mizushima H, Zhou CJ, Dohi K, Horai R, Asano M, Iwakura Y, Hirabayashi T, Arata S, Nakajo S, Takaki A, Ohtaki H, Shioda S. Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1. J Comp Neurol. 2002 Jun 24;448(2):203-16.
  • Oguro T, Takahashi Y, Ashino T, Takaki A, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Yoshida T. Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver. FEBS Lett. 2002 Apr 10;516(1-3):63-6.

2001N
  • Nakae S, Asano M, Horai R, Iwakura Y. Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production. Immunology. 2001 Dec;104(4):402-9.
  • Saijo S, Asano M, Horai R, Yamamoto H, Iwakura Y. Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells. Arthritis Rheum. 2002 Feb;46(2):533-44.
  • Nakae S, Naruse-Nakajima C, Sudo K, Horai R, Asano M, Iwakura Y. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity. Int Immunol. 2001 Dec;13(12):1471-8.
  • Morita Y, Maravei DV, Bergeron L, Wang S, Perez GI, Tsutsumi O, Taketani Y, Asano M, Horai R, Korsmeyer SJ, Iwakura Y, Yuan J, Tilly JL. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ. 2001 Jun;8(6):614-20.
  • Kotani, N., Asano, M., Iwakura, Y. and Takasaki, S.: Knockout of mouse 1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins. Biochem. J. 357(Pt 3):827-34, 2001.
  • Nakae, S., Asano, M., Horai, R., Sakaguchi N. and Iwakura Y.: IL-1 enhances T cell-dependent antibody production through induction of CD40L and OX40 on T cells. J. Immunol.167(1):90-97, 2001.
  • Boutin, H., LeFeuvre, R.A., Smith, C., Horai, R., Asano, M., Iwakura, Y. and Rothwell, N.J.: Role of IL-1 and IL-1 in ischaemic brain damage. J Neurosci. 2001 Aug 1;21(15):5528-34.
  • Ozaki, H., Watanabe, Y., Takahashi, K., Kitamura, K., Tanaka, A., Urase, K., Momoi, T., Sudo, K., Sakagami, J., Asano, M., Iwakura, Y. and Kawakami, K.: Six4, putative myogenin gene regulator, is not essential for mouse embryonal development. Mol. Cell. Biol. 21: 3343-3350, 2001.
  • Naruse-Nakajima, C., Asano, M. and Iwakura, Y.: Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech. Dev. 102: 95-105, 2001.
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